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. 2005 Sep 6;93(7):774–780. doi: 10.1038/sj.bjc.6602780

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Copyright © 2005 Cancer Research UK

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(A) Expression of E2_14k in soluble extracts of gastrocnemius muscles from mice bearing the MAC16 tumour and with different extents of weight loss, as detected by immunoblotting. (B) Densitometric analysis of band intensities in (A) reported in arbitary units. (C) Expression of E2 mRNA in gastrocnemius muscle from mice with different extends of weight loss. (D) Total protein degradation, as measured by tyrosine release, in gastrocnemius muscle of mice with different extents of weight loss. The figures represent protein degradation inhibited by lactacystin (10 μM). Differences from animals without weight loss are expressed as b, P<0.01 or c, P< 0.001.