Table 2. Haematologic and nonhaematologic toxicity of second-line IC and C.
|
Grade 1
|
Grade 2
|
Grade 3
|
Grade 4
|
|||||
|---|---|---|---|---|---|---|---|---|
| IC | C | IC | C | IC | C | IC | C | |
| Anaemia | 38 (54) | 35 (52) | 23 (32) | 19 (28) | 4 (6) | — | — | 1 (2)a |
| Neutropenia | 11 (16) | 9 (13) | 13 (18) | 7 (10) | 12 (17) | 3 (4) | 10 (14)b | — |
| Thrombocytopenia | 18 (25) | 12 (18) | 3 (4) | 1 (2) | 3 (4) | 2 (3) | 2 (3) | — |
| Nausea/vomiting | 11 (16) | 4 (6) | 18 (25) | 13 (19) | 8 (11) | 3 (4) | 1 (1)c | — |
| Diarrhoea | 8 (11) | 3 (4) | 16 (23) | 2 (3) | 14 (20) | 1 (2) | 5 (7)d | 1 (2) |
| Mucositis | 2 (3) | 2 (3) | — | — | — | — | — | 1 (2) |
| Neurotoxicity | 2 (3) | 4 (6) | 3 (4) | 3 (4) | — | 1 (2) | — | — |
| Asthenia | 19 (27) | 8 (12) | 13 (18) | 12 (18) | 8 (11) | 7 (10) | — | 2 (3) |
| Fluid retention syndrome | 2 (3) | — | 2 (3) | 1 (2) | — | 1 (2) | 1 (1) | 1 (2) |
| Non-neutropenic infection | 9 (13) | 6 (9) | — | — | — | — | — | 1 (2) |
The results are expressed as the ‘number of patients’. In parentheses: % of patients.
a
Grade 2–4 anaemia; P=0.283.
b
Grade 3 and 4 neutropenia; P=0.001.
c
Grade 3 and 4 nausea/vomiting; P=0.083.
d
Grade 3 and 4 diarrhoea; P=0.0001.