Table 3. Description of events by treatment arm.

Type of event	5FU n=308	5FU-LEV n=357	5FU-FA n=312	5FU-FA-LEV n=350	Total n=1327
First event, n (%)
Locoregional relapse
Anastomosis or perianastomosis	5 (1.6)	2 (0.6)	2 (0.6)	5 (1.4)	14 (1.1)
Abdominal or pelvic lymphnodes	4 (1.2)	3 (0.8)	2 (0.6)	6 (1.7)	15 (1.1)
Abdominal or pelvic masses	17 (5.5)	22 (6.1)	15 (4.8)	17 (4.9)	71 (5.3)
Peritoneal carcinosis	7 (2.3)	4 (1.1)	2 (0.6)	4 (1.1)	17 (1.3)
Distant metastases
Liver	28 (9.1)	32 (9.0)	27 (8.6)	31 (8.9)	118 (8.9)
Lung	7 (2.3)	8 (2.2)	9 (2.9)	4 (1.1)	28 (2.1)
Bone	2 (0.6)	2 (0.6)	1 (0.3)	2 (0.6)	7 (0.5)
Soft tissues	1 (0.3)	1 (0.3)	—	1 (0.3)	3 (0.2)
Combination of distant sites	8 (2.6)	2 (0.6)	5 (1.6)	5 (1.4)	20 (1.5)
Locoregional+distant	11 (3.6)	10 (2.8)	7 (2.2)	10 (2.9)	38 (2.9)
Other or unknown site	3 (1.0)	8 (2.2)	6 (1.9)	6 (1.7)	23 (1.7)
Death without relapse	10 (3.2)	13 (3.6)	12 (3.8)	8 (2.3)	43 (3.2)
Death, n (%)	67 (21.7)	65 (18.2)	67 (21.5)	65 (18.6)	264 (19.9)
Second primary, n (%)
Colorectal	3 (1.0)	2 (0.6)	2 (0.6)	5 (1.4)	12 (0.9)
Leukemia	—	1 (0.3)	—	—	1 (0.07)
Breast	1 (0.3)	1 (0.3)	1 (0.3)	1 (0.3)	4 (0.3)
Lung	—	1 (0.3)	1 (0.3)	1 (0.3)	3 (0.2)
Thymoma	1 (0.3)	—	—	—	1 (0.07)
Bladder	—	1 (0.3)	—	—	1 (0.07)
Prostate	—	—	1 (0.3)	1 (0.3)	2 (0.1)
Thyroid	—	—	2 (0.6)	—	2 (0.1)