Table 2. Plasma pharmacokinetics of NU7026 and its metabolites NU7199 and NU7200 following administration of NU7026 at 5 mg kg−1 i.v. to mice.
| Compound | Cmax (nmol l−1) | Tmax (h) | AUC last (nmol l h−1) | t1/2 (h) | Cl obs. (l h−1) | Vd (l) |
|---|---|---|---|---|---|---|
| 7026 | 5123 | 0 | 3616 | 1.22 | 0.09 | 0.16 |
| 7199 | 705 | 0.25 | 414 | 0.2 | 0.82 | 0.23 |
| 7200 | 293 | 0.25 | 143 | 0.16 | 2.44 | 0.55 |
Parameters are Cmax (maximum concentration), AUC (area under the concentration vs time curve), Cl (Clearance), t1/2 (half-life), Vd (volume ofz distribution based on the elimination phase).