Table 3. Plasma pharmacokinetics of NU7026 and NU7107 following administration at 20 mg kg−1 i.p. to mice.
| Compound | Cmax (nmol l−1) | Tmax (h) | AUC last (nmol l h−1) | t1/2 (h) | Cl obs. (l h−1) | Vd (l) |
|---|---|---|---|---|---|---|
| 7026 | 5123 | 0.083 | 7349 | 0.87 | 0.44 | 0.55 |
| 7107 | 10390 | 0.25 | 12165 | 0.79 | 0.11 | 0.12 |
Parameters are Cmax (maximum concentration), AUC (area under the concentration vs time curve), Cl (clearance), t1/2 (half-life), Vd (volume of distribution based on the elimination phase).