Table 2. Methylation of DRM/Gremlin, HPP1, and RUNX3 in human cancers.
|
No. methylated (%)
|
||||
|---|---|---|---|---|
| Samples | Total no. | DRM/Gremlin | HPP1 | RUNX3 |
| Adult tumours | 367 | |||
| Primary NSCLC | ||||
| Adenocarcinoma | 60 | 22 (37) | 18 (30) | 13 (22) |
| Squamous cell carcinoma | 51 | 40 (78) | 15 (29) | 8 (16) |
| Large cell carcinoma | 6 | 5 (83) | 4 (67) | 4 (67) |
| Primary SCLC | 5 | 3 (60) | 2 (40) | 0 |
| Bronchial carcinoid | 18 | 0 | 0 | 0 |
| Malignant mesothelioma | 63 | 38 (60) | 22 (35) | 21 (33) |
| Breast cancer | 37 | 20 (54) | 13 (35) | 8 (22) |
| Prostate cancer | 50 | 10 (20) | 19 (38) | 5 (10) |
| Bladder cancer | 57 | 29 (51) | 20 35) | 24 (42) |
| Lymphoma | 20 | 10 (50) | 6 (30) | 1 (5) |
| Paediatric tumours | 150 | |||
| Osteosarcoma | 10 | 1 (10) | 0 | 5 (50) |
| Wilm’s tumour | 25 | 0 | 0 | 0 |
| Neuroblastoma | 27 | 0 | 0 | 0 |
| Rhabdomyosarcoma | 17 | 1 (6) | 0 | 0 |
| Medulloblastoma | 12 | 0 | 0 | 0 |
| Hepatoblastoma | 22 | 0 | 0 | 0 |
| Ewing sarcoma | 7 | 0 | 0 | 0 |
| Retinoblastoma | 30 | 0 | 0 | 0 |
| Normal tissues | 138 | |||
| Lung tissuesa and NHBEC | 51 | 1 (2) | 0 | 0 |
| Mesothelial cells | 3 | 0 | 0 | 0 |
| Breast tissuesa | 23 | 0 | 0 | 0 |
| Protate tissuesa | 4 | 0 | 0 | 0 |
| Bladder tissuesa | 5 | 0 | 0 | 0 |
| Peripheral blood lymphocytesb | 14 | 0 | 0 | 0 |
a
Adjacent to resected tumours.
b
From healthy volunteers.