Table 1. Association between CASP8 variants D302H (rs1045485) and the ±6N promoter variant rs3834129 with colorectal cancer and results are also shown for the 8q24.21 variant rs6983267.
| Gene/locus | Variant | Genotype | Cases (%) | Controls (%) | OR (95% CI) |
|---|---|---|---|---|---|
| CASP8 | D302H (rs1045485) | CC | 2890 (75%) | 2703 (74%) | 1.00 (ref) |
| CG | 894 (23%) | 867 (24%) | 1.09 (0.75–1.58) | ||
| GG | 59 (2%) | 61 (2%) | 1.13 (0.78–1.63) | ||
| CG/GG | 953 (25%) | 928 (26%) | 0.96 (0.86–1.07) | ||
| Ptrend=0.67 | |||||
| CASP8 | −/CTTACT (rs3834129) | Ptrend=0.97 | |||
| 6N ins/ins | 995 (26%) | 892 (24%) | 1.00 | ||
| 6N del/ins | 1897 (49%) | 1872 (51%) | 0.91 (0.81–1.01) | ||
| 6N del/del | 987 (25%) | 897 (25%) | 0.99 (0.87–1.12) | ||
| 6Ndel/del +6N del/ins | 2884 (74%) | 2769 (76%) | 0.93 (0.84–1.04) | ||
| Ptrend=0.83 | |||||
| 8q24.21 | rs6983267 | GG | 1102 (31%) | 678 (26%) | 1.00 (ref) |
| GT | 1824 (51%) | 1297 (50%) | 0.86 (0.76–0.97) | ||
| TT | 657 (18%) | 604 (23%) | 0.67 (0.57–0.77) | ||
| GT/TT | 2481 (69%) | 1901 (73%) | 0.80 (0.72–0.90) | ||
| Ptrend=1.13 × 10−6 |
Test of HWE: rs3834129, P=0.09; rs1045485, P=0.37; rs6983267, P=0.74. Crude odds ratios are presented. Ptrend, test of trend across genotypes. Adjustment for age and sex made no difference to metrics (data not shown).