Table 4. Estimated BRCA1 and BRCA2 allele frequencies and relative hazards for model σp 2=σm 2 in Table 3.
|
BRCA1
|
BRCA2
|
|||||
|---|---|---|---|---|---|---|
| Age (years) | Frequency (95% Cl) | BC RH (95% Cl) | OC RH (95% Cl) | Frequency (95% Cl) | BC RH (95% Cl) | OC RH (95% Cl) |
| 0.0006 (0.04–0.10%) | 0.0010 (0.06–0.15%) | |||||
| 20–29 | 44.9 (25.4–79.2) | 1.0 | 21.1 (10.9–40.6) | 1.0 | ||
| 30–39 | 26.2 (18.3–37.3) | 39.0 (17.2–88.5) | 14.8 (10.2–21.4) | 1.0 | ||
| 40–49 | 19.9 (14.3–27.7) | 68.4 (43.5–107.5) | 11.0 (7.8–15.5) | 3.9 (0.8–19.4) | ||
| 50–59 | 9.6 (5.8–15.9) | 26.2 (13.6–50.2) | 9.7 (6.3–14.7) | 19.4 (10.4–36.3) | ||
| 60–69 | 8.3 (4.0–17.3) | 37.8 (17.8–80.2) | 9.1 (5.1–16.1) | 7.1 (1.8–28.3) | ||
BC=breast cancer; OC=ovarian cancer; RH=relative hazard.
RH are estimated relative to the cohort-specific population incidences. RH assumed to be constant across birth cohorts.