Table 5. Age-specific observed (Collaborative Group in Hormonal Factors in Breast Cancer, 2001) and predicted FRRs of breast cancer associated with having an affected mother.
|
Predicted FRR
|
||||
|---|---|---|---|---|
| Age (years) | σp2=σm2a | σp2(t)=σm2(t)=α+βt | σp2(t)=σm2(t)=α+βt b | Observed FRR (95% Cl) |
| 25 | 5.3 | 6.7 | 6.0 | |
| 30 | 3.1 | 3.9 | 5.8 | 5.7 (2.7–11.8) |
| 35 | 2.9 | 3.4 | 3.5 | |
| 40 | 2.4 | 2.6 | 2.6 | |
| 45 | 2.2 | 2.3 | 2.2 | 2.0 (1.5–2.8) |
| 50 | 2.0 | 1.9 | 1.9 | |
| 55 | 1.9 | 1.7 | 1.7 | 1.6 (1.2–2.1) |
| 60 | 1.8 | 1.5 | 1.5 | |
| 65 | 1.7 | 1.4 | 1.4 | 1.4 (1.2–1.7) |
| 70 | 1.7 | 1.3 | 1.3 | |
FRR=familial relative risk.
a
These models refer to the models in Table 3. BRCA1/2 log-relative hazards assumed to be constant in each decade of age.
b
BRCA1/2 log-relative hazards assumed to be piecewise linear functions of age.