Table 3. Incidence of CTC grade 3 and grade 4 haematologic and non-haematologic toxicity by cohorta.
|
Gem d1,8; Dox d2 (n=20)
|
Gem d1,8; Dox d1 (n=20)
|
Gem d2,8; Dox d1 (n=25)
|
||||
|---|---|---|---|---|---|---|
| Toxicityb | Grade 3 | Grade 4 | Grade 3 | Grade 4 | Grade 3 | Grade 4 |
| Anaemia | 5 | 3 | 1 | 1 | 1 | 1 |
| Neutropenia | 5 | 7 | 6 | 3 | 4 | 2 |
| Leukopenia | 2 | 0 | 1 | 0 | 0 | 0 |
| Thrombocytopenia | 4 | 1 | 2 | 0 | 0 | 1 |
| ALT (SGPT) | 1 | 0 | 0 | 0 | 0 | 1 |
| Hypokalemia | 1 | 3 | 0 | 1 | 0 | 0 |
| Hyponatremia | 1 | 0 | 0 | 1 | 1 | 0 |
| Hypernatremia | 0 | 1 | 0 | 0 | 0 | 0 |
| Hypoglycemia | 0 | 0 | 0 | 0 | 0 | 1 |
| Fatigue | 2 | 0 | 1 | 1 | 1 | 0 |
| Oral/pharyngeal mucositis | 5 | 1 | 0 | 0 | 2 | 0 |
| Dehydration | 5 | 0 | 0 | 0 | 1 | 0 |
| Vomiting | 3 | 3 | 0 | 0 | 1 | 0 |
| Diarrhoea | 4 | 0 | 1 | 0 | 0 | 0 |
| Febrile neutropenia | 3 | 4 | 0 | 0 | 0 | 0 |
| Infection with grade 3/4 neutropenia | 1 | 1 | 0 | 2 | 0 | 1 |
ALT=alanine aminotransferase; d=day; Dox=doxorubicin; Gem=gemcitabine; SGPT=serum glutamic pyruvic transaminase.
a
Cohort defined by cycle-1 schedule of gemcitabine plus doxorubicin.
b
Toxicities were graded according to Common Toxicity Criteria (version 2.0) and listed according to maximum grade reported. Includes all toxicities recorded as grade 4 and all grade 3 toxicities that occurred in >2 patients.