Table 3. Relationship between survivin, survivin-2B and survivin-ΔEx3 and established prognostic factors in breast cancer.
|
Median levels (OD units/relative to GAPDH)
|
||||
|---|---|---|---|---|
| Characteristic | n | Survivin | Survivin-2B | Survivin-ΔEx3 |
| Size (cm) | ||||
| ⩽2 | 34 | 0.488 | 0.096 | 0.134 |
| >2 | 114 | 0.523 | 0.110 | 0.142 |
| Nodal status | ||||
| Positive | 85 | 0.490 | 0.113 | 0.118 |
| Negative | 63 | 0.534 | 0.103 | 0.157 |
| Histology | ||||
| Ductal(D) | 115 | 0.549 | 0.112 | 0.146* |
| Lobular (L) | 25 | 0.386 | 0.075 | 0.084 |
| Mixed D+L | 11 | 0.405 | 0.114 | 0.159 |
| Grade | ||||
| 1+2 | 57 | 0.495 | 0.104 | 0.133 |
| 3 | 77 | 0.568 | 0.124 | 0.154 |
| ER status | ||||
| Positive | 102 | 0.508 | 0.108 | 0.146 |
| Negative | 41 | 0.519 | 0.111 | 0.146 |
| PR status | ||||
| Positive | 56 | 0.503 | 0.089 | 0.143 |
| Negative | 90 | 0.525 | 0.125 | 0.154 |
*
Denotes a P-value of <0.05.