Table 3. Worst nonhaematologic CTC toxicity grade per patient for all cycles.
Docetaxel
|
Docetaxel–Irinotecan
|
||||
---|---|---|---|---|---|
Toxicity | No. | % | No. | % | P |
ASAT | NS | ||||
1 | 6 | 11 | 4 | 8 | |
2 | 1 | 2 | 0 | 0 | |
3 | 0 | 0 | 1 | 2 | |
ALAT | NS | ||||
1 | 20 | 36 | 18 | 35 | |
2 | 4 | 7 | 3 | 6 | |
Creatinine | NS | ||||
1 | 21 | 38 | 8 | 15 | |
2 | 1 | 2 | 3 | 6 | |
3 | 0 | 0 | 1 | 2 | |
Mucositis | NS | ||||
1 | 8 | 14 | 5 | 10 | |
2 | 1 | 2 | 0 | 0 | |
Nausea | NS | ||||
1 | 15 | 27 | 14 | 27 | |
2 | 5 | 9 | 12 | 23 | |
Vomiting | NS | ||||
1 | 11 | 20 | 9 | 17 | |
2 | 4 | 7 | 4 | 8 | |
Diarrhoea | <0.01 | ||||
1 | 11 | 20 | 21 | 40 | |
2 | 4 | 7 | 11 | 21 | |
3 | 1 | 2 | 7 | 14 | |
Fever | NS | ||||
1 | 5 | 9 | 2 | 4 | |
2 | 2 | 4 | 0 | 0 | |
Infections | NS | ||||
1 | 3 | 5 | 2 | 4 | |
2 | 0 | 0 | 2 | 4 | |
3 | 1 | 2 | 0 | 0 | |
Alopecia | <0.05 | ||||
1 | 15 | 27 | 6 | 12 | |
2 | 16 | 29 | 25 | 48 | |
Skin reactions | NS | ||||
1 | 2 | 4 | 0 | 0 | |
2 | 3 | 5 | 0 | 0 | |
Sensory neuropathy | NS | ||||
1 | 13 | 23 | 10 | 19 | |
2 | 4 | 7 | 1 | 2 | |
Motoric neuropathy | NS | ||||
1 | 2 | 4 | 0 | 0 | |
2 | 0 | 0 | 0 | 0 | |
3 | 0 | 0 | 1 | 2 | |
Anorexia | NS | ||||
1 | 16 | 29 | 16 | 31 | |
2 | 4 | 7 | 4 | 8 | |
Fatigue | NS | ||||
1 | 23 | 41 | 13 | 25 | |
2 | 12 | 21 | 18 | 35 | |
Nail changes | 0.052 | ||||
1 | 5 | 9 | 0 | 0 | |
2 | 1 | 2 | 0 | 0 | |
Myalgia | <0.05 | ||||
1 | 12 | 21 | 3 | 6 | |
2 | 2 | 4 | 0 | 0 | |
Arthralgia | <0.05 | ||||
1 | 5 | 9 | 0 | 0 |
NS=Not significant.