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. 2005 Jan 14;92(1):47–54. doi: 10.1038/sj.bjc.6602267

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Copyright © 2005 Cancer Research UK

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.

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Simulation of RFS in patients with 10 or more positive axillary nodes following maximally intensive therapy, assuming different proportions of patients with sensitive tumours ranging from 0 to 1.0, in 0.1 increments. Treatment of maximally tolerated intensity is assumed to produce a 9 log cell kill in sensitive tumours, and is assumed to produce no effect on resistant tumours. For reference, the value for RFS at 5 years following treatment of maximal intensity using the Peters regimen (Peters et al, 2000) is shown (open circle), corresponding to an estimated probability of a chemosensitive tumour equal to 0.48.