Table 2. ORs for breast cancer risk associated with alcohol intake stratified by ADH1B genotype.
|
ADH1B*1/*1 genotype
|
ADH1B*2 carrier
|
|||||
|---|---|---|---|---|---|---|
| Cases/controls | ORa | 95% CI | Cases/controls | ORa | 95% CI | |
| Alcohol consumption (g day on average−1) | ||||||
| 0 | 101/147 | 1 (Ref) | 16/29 | 1 (Ref) | ||
| 1–5 | 200/407 | 0.74 | 0.54–1.01 | 33/47 | 0.81 | 0.34–1.91 |
| 6–11 | 104/226 | 0.70 | 0.49–0.99 | 9/13 | 0.87 | 0.25–3.02 |
| 12+ | 143/193 | 1.12 | 0.78–1.59 | 7/20 | 0.29 | 0.08–1.00 |
| P-value for trendb | 0.03 | 0.04 | ||||
ADH1B=alcohol dehydrogenase 1B; OR=odds ratio; CI=confidence interval.
a
ORs stratified for age by 5-year intervals; additional adjustment was made for first-degree family history (yes/no), parity (0, 1–2, 3+ children), menopausal status (pre-, postmenopausal, unknown), education (low, intermediate and high) and smoking status (never, former and current active smoking) as categorical variables and breastfeeding (total duration in months) as continuous variable;
b
Test for linear trend (mean of categories used).