Table 2. Fluoropyrimidine toxicity according to treatment arm and dose of fluoropyrimidine.
|
Number of patients (%)
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Toxicity (grade 3/4) | ECF 200 | EOF 200 | ECX 500 | EOX 500 | ECX 625 | EOX 625 | |||
| Stomatitis | 0 (0) | 5 (10) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |||
| Palmar-plantar erythema | 2 (4) | 1 (2) | 1 (4) | 2 (6) | 3 (16) | 1 (6) | |||
| Diarrhoea | 1 (2%) | 5 (10) | 0 (0) | 2 (6) | 0 (0) | 1 (6) | |||
| Any 5-FU-related toxicity | 13 (13.7) | 5 (8.4) | 5 (14.7) | ||||||
| 95% CI 7.4–22 | 95% CI 2.8–18.7 | 95% CI 4.9–31 | |||||||
ECF=epirubicin, cisplatin, 5-fluorouracil; ECX=epirubicin, cisplatin, capecitabine; EOF=epirubicin, oxaliplatin, 5-fluorouracil; EOX=epirubicin, oxaliplatin, capecitabine.