Table 4. Non-fluoropyrimidine toxicity according to fluoropyrimidine dose.
|
ECF 200
|
EOF 200
|
ECX 500
|
EOX 500
|
ECX 625
|
EOX 625
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Toxicity (grade 3/4) | No. of pts/total | % | No. of pts/total | % | No. of pts/total | % | No. of pts/total | % | No. of pts/total | % | No. of pts/total | % |
| Nauseaa | 2/47 | 4 | 7/50 | 14 | 1/27 | 4 | 2/32 | 6 | 0/16 | 0 | 2/16 | 12 |
| Alopeciab | 21/47 | 50 | 18/50 | 36 | 12/27 | 44 | 10/32 | 31 | 5/16 | 31 | 3/16 | 19 |
| Lethargy | 8/46 | 17 | 10/50 | 20 | 3/27 | 11 | 5/32 | 16 | 1/16 | 6 | 3/16 | 19 |
| Peripheral neuropathya | 0/47 | 0 | 3/50 | 6 | 1/27 | 4 | 0/32 | 0 | 0/16 | 0 | 2/16 | 12 |
| Neutropenia | 16/47 | 34 | 12/49 | 24 | 9/25 | 36 | 15/32 | 46 | 6/15 | 40 | 4/16 | 25 |
| Thrombocytopeniaa | 2/47 | 4 | 4/49 | 8 | 4/26 | 15 | 2/32 | 6 | 0/15 | 0 | 1/16 | 6 |
| Infectiona | 6/47 | 13 | 10/50 | 20 | 1/27 | 4 | 2/32 | 6 | 1/16 | 6 | 4/16 | 25 |
| Febrile neutropenia | 2/24 | 8 | 4/29 | 14 | 1/10 | 10 | 0/14 | 0 | 0/14 | 0 | 3/16 | 19 |
| Anaemia | 8/47 | 17 | 2/49 | 4 | 2/26 | 8 | 3/32 | 9 | 1/15 | 7 | 1/16 | 6 |
a
No grade 4 toxicity.
b
CTC grade 2 alopecia.
Pts=patients; ECF=epirubicin, cisplatin, 5-fluorouracil; ECX=epirubicin, cisplatin, capecitabine; EOF=epirubicin, oxaliplatin, 5-fluorouracil; EOX=epirubicin, oxaliplatin, capecitabine.