Table 2. Response to therapy in the entire treatment period.

	Number (%) of patients
Response category	Irinotecan+5-FU/LV (N=56)	Etoposide+5-FU/LV (N=58)
CR	2 (4)	0
PR	22 (39)	14 (24)
NC	11 (20)	10 (17)
PD	13 (23)	27 (47)
Missing	8 (14)	7 (12)
Overall response (CR+PR)	24 (43)	14 (24)
	RR (95% CI), P-value
	0.56 (0.33–0.97), P=0.0467
Disease control (CR+PR+NC)	35 (63)	24 (41)

5-FU=5-fluorouracil; LV=leucovorin; CR=Complete response; PR=partial response; NC=no change; PD=progressive disease; RR=risk ratio; CI=confidence interval.