Table 2. Long-term toxicity.
| Test | N a | Prechemo | 1 year (± 3 mths) postchemo | P-value for changeb |
|---|---|---|---|---|
| Audiometry | ||||
| Median loss at 2 kHz (IQ range) | 37 | 5 dB (0–10) | 5 dB (0–10) | 0.24 |
| Median loss at 4 kHz (IQ range) | 38 | 10 dB (5–15) | 10 dB (8–16) | 0.24 |
| Median loss at 8 kHz (IQ range) | 37 | 10 dB (5–23) | 15 dB (10–30) | 0.008 |
| Pulmonary function tests | ||||
| Mean KCO %predicted (s.d.) | 23 | 102 (13) | 97 (17) | 0.03 |
| Mean FEV %predicted (s.d.) | 28 | 106 (13) | 106 (11) | 1.00 |
| Mean FVC %predicted (s.d.) | 29 | 110 (13) | 109 (11) | 0.43 |
| Mean TLC %predicted (s.d.) | 22 | 105 (13) | 104 (14) | 0.55 |
| Hormones | ||||
| Median LH (IQ range) | 34 | 4.3 (3.6–6.7) | 5.7 (4.2–7.5) | 0.023 |
| Median FSH (IQ range) | 34 | 7.8 (5.9–9.1) | 9.0 (6.9–11.4) | <0.001 |
| Median testosterone (IQ range) | 30 | 14.3 (12.0–19.6) | 16.7 (11.3–20.0) | 0.57 |
KCO=transfer coefficient for carbon monoxide; FEV=forced expiratory volume; FVC=forced vital capacity; TLC=total lung capacity; LH=luteinising hormone; FSH=follicle-stimulating hormone.
IQ range=interquartile range; s.d.=standard deviation.
a
Number of patients with both baseline and follow-up values.
b
Paired t-test for pulmonary function test comparisons, Wilcoxon's test elsewhere.