Table 3. Treatment effects upon number and size of ACF.
Group | Treatment | Mice (n) | No. of ACF per colon | No. of ACF per 104 crypts | No. of aberrant crypts per ACF |
---|---|---|---|---|---|
1 | Water only | 5 | 0.40±0.24 | 0.09±0.04 | 0.60±0.28 |
2 | DMSO only | 5 | 0.20±0.20 | 0.07±0.04 | 0.40±0.25 |
3 | Continuous 1% λCgN | 5 | 0.80±0.20 | 0.21±0.04 | 1.60±0.34 |
4 | Continuous 4% λCgN | 5 | 1.00±0 | 0.25±0.005 | 2.40±0.24 |
5 | MNU only | 10 | 3.90±0.23 | 1.37±0.015 | 4.00±0.17 |
6 | MNU+1 × 7-day cycle 1% λCgN | 10 | 5.00±0.29 | 1.67±0.18 | 4.00±0.16 |
7 | MNU+1 × 7-day cycle 4% λCgN | 10 | 4.90±0.23 | 1.56±0.14 | 5.90±0.21 |
8 | MNU+3 × 7-day cycle 1% λCgN | 10 | 5.80±0.24 | 2.04±0.14 | 6.58±0.33 |
9 | MNU+3 × 7-day cycle 4% λCgN | 10 | 6.70±0.21 | 2.52±0.39 | 5.80±0.17 |
10 | MNU+continuous 1% λCgN | 10 | 5.00±0.25 | 1.65±0.14 | 5.90±0.22 |
11 | MNU+continuous 4% λCgN | 10 | 6.80±0.29 | 2.95±0.21 | 5.38±0.26 |
ACF=aberrant crypt foci; DMSO=dimethylsulphoxide; λCgN= lambda carrageenan; MNU=N-methyl-N-nitrosourea.