Table 2. Analysis of VH genes from cases of MALT lymphoma before eradication.
|
Mutations
|
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|---|---|---|---|---|---|---|---|---|---|---|
| Case | GL donor | VH family | % Homology | FR | R/S | CDR | R/S | CDR/FR | D segment | JH segment |
| 1a | YAC-9 | VH3 | 93.7 | 5 | 0.7 | 5 | >5 | 1 | D21/9-DAI or DA4 | JH4 |
| 1b | DP-77 | VH3 | 88.2 | 8 | 1.7 | 8 | 7 | 1.3 | H23-D-DLR1 | JH4 |
| 2 | DP-77 | VH3 | 98.2 | 1 | >1 | 2 | >2 | 2 | H23-D reverse | JH4 |
| 3 | DP-46 | VH3 | 96.4 | 3 | 2 | 3 | >3 | 1 | DN1 | JH4 |
| 4 | DP-54 | VH3 | 95.4 | 4 | 3 | 2 | >2 | 0.5 | DXP′l | JH4 |
| 5a | V4–31 | VH4 | 92.0 | 6 | 2 | 2 | >2 | 0.3 | DHQ52 | JH4 |
MALT=mucosa-associated lymphoid tissue; GL=germ line. When all mutations induced replacement (S=0), results are exposed as > number of replacements observed.
a
After eradication of H. pylori.