Table 3. Distribution of mutations in the tumour-derived V_H sequences.

		Expected		Observed
Case	Region	R	S	R	S	P a
1a	CDR	2	1	5	0
						0.04
	FR	5	2	2	3
1b	CDR	4	1	7	1
						0.02
	FR	8	3	5	3
2	CDR	0	0	2	0
						0.10
	FR	2	1	1	0
3	CDR	2	0	3	0
						0.09
	FR	3	1	2	1
4	CDR	2	0	2	0
						0.27
	FR	3	1	3	1
5	CDR	2	0	2	0
						0.30
	FR	4	2	4	2

^aP is the probability of obtaining the number of R mutations found in the CDR by chance.