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. 2005 Feb 8;92(4):729–735. doi: 10.1038/sj.bjc.6602385

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Copyright © 2005 Cancer Research UK

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Recombinant human endostatin reduces tumour cell adhesion under flow conditions. (A) C26 cells were allowed to adhere to a confluent layer of TNF-α-stimulated HUVECs under flow conditions for 5 min and this was recorded on a videotape. The number of adherent tumour cells per mm² was determined by off-line analysis of the video images. Recombinant human endostatin reduced the number of adhered tumour cells to stimulated HUVECs when compared to citrate buffer control by 41% (P=0.04). (B) Immunofluorescence and multiphoton laser scanning microscopy visualised C26 tumour cell adhesion to HUVECs. After perfusion with tumour cells in full blood, the coverslips were fixed and stained with Hoechst (blue) to stain nuclei, Phalloidin-TRITC (red) to stain filamentous actin and anti-fibrinogen (green) to visualise the extracellular matrix. Platelets are indicated by arrows.