Table 2. Measurement of the antiproliferative effect of ATRA and 13cisRA in the absence or presence of R116010 or acitretin in SH-SY5Y cellsa.
|
Incubation
| ||
|---|---|---|
| RA isomer | Inhibitor (1 μM) | Growth inhibition (% untreated cell growth) |
| R116010 | 96.4±2.4 | |
| Acitretin | 66.5±1.9 | |
| 0.01 μM ATRA | — | 60.3±2.9 |
| R116010 | 48.9±2.2 | |
| Acitretin | 52.2±2.3 | |
| 0.1 μM 13cisRA | — | 53.8±2.5 |
| R116010 | 42±1.9 | |
| Acitretin | 55.7±3.1 | |
Results are expressed as mean±s.e.m. from n⩾3 experiments.