Table 2. Measurement of the antiproliferative effect of ATRA and 13cisRA in the absence or presence of R116010 or acitretin in SH-SY5Y cellsa.
Incubation
| ||
---|---|---|
RA isomer | Inhibitor (1 μM) | Growth inhibition (% untreated cell growth) |
R116010 | 96.4±2.4 | |
Acitretin | 66.5±1.9 | |
0.01 μM ATRA | — | 60.3±2.9 |
R116010 | 48.9±2.2 | |
Acitretin | 52.2±2.3 | |
0.1 μM 13cisRA | — | 53.8±2.5 |
R116010 | 42±1.9 | |
Acitretin | 55.7±3.1 |
Results are expressed as mean±s.e.m. from n⩾3 experiments.