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. 2005 Feb 1;92(4):760–769. doi: 10.1038/sj.bjc.6602373

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Copyright © 2005 Cancer Research UK

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Silencing of the Testisin gene in testicular germ cell tumours is associated with DNA hypermethylation. (A) Testisin mRNA expression in representative primary human tissue specimens. RNA isolated from testicular tumour (T) and unaffected adjacent normal tissues (N) from individual patients was evaluated by RT–PCR for Testisin mRNA expression. β-Actin mRNA was monitored as a measure of mRNA concentration and integrity. The tables show the results of sequence analysis of the Testisin 5′ CpG island of bisulphite treated genomic DNA isolated from matched primary tissues from individual patients: unaffected ‘normal’ testicular tissue adjacent to tumour (B) and testicular tumour tissues (C). The symbols and the percentage methylated CpG sites were calculated as described in the legend to Figure 1. The data are representative of a minimum of two independent bisulphite sequencing experiments.