Table 2. Comparison of significant high-frequency genomic imbalances (⩾20%; see Table 1) in human HCCs with HBV- (n=428) and HCV-aetiology (n=338).
|
HBV
*
|
HCV*
|
|||||
|---|---|---|---|---|---|---|
| Chromosome | Negative (n=184) | Positive (n=244) | Negative (n=228) | Positive (n=110) | ||
| 1q (gain; %) | 50.5 | P=0.625 | 53.3 | 53.5 | P=0.201 | 45.5 |
| 4q (loss; %) | 19.6 | P<0.0005 | 43.4 | 26.3 | P=0.896 | 27.3 |
| 6p (gain; %) | 21.2 | P=0.488 | 24.2 | 24.1 | P=0.121 | 16.4 |
| 8p (loss; %) | 29.3 | P=0.019 | 40.6 | 36.0 | P=0.004 | 20.0 |
| 8q (gain; %) | 37.0 | P=0.05 | 46.7 | 42.1 | P=0.194 | 34.5 |
| 13q (loss; %) | 19.6 | P=0.008 | 31.1 | 28.5 | P=0.363 | 23.6 |
| 16q (loss; %) | 18.5 | P<0.0005 | 41.8 | 28.1 | P=0.898 | 27.3 |
| 17p (loss; %) | 25.0 | P=0.108 | 32.4 | 24.1 | P=0.19 | 30.9 |
| 17q (gain; %) | 17.4 | P=0.389 | 20.9 | 19.3 | P=0.766 | 17.3 |
*
Significant differences are highlighted in bold (P<0.05).