Table 2. Odds ratios for invasive cervical carcinoma in relation to the mean normalised viral load of individual HPV types or group of closely related HPV types.

			95% CI
Limits	Cases/controls	OR	Lower limit	Upper limit	P-value
Single smear cohort
HPV 16	34/473	Ref.b	—	—	—
Negative	4/10	5.565	1.658	18.673	0.0055
0<VLa⩽0.44	5/9	7.729	2.454	24.342	0.0005
0.44<VLa⩽2.47	8/6	18.549	6.087	56.524	0.0001
2.47<VLa⩽18.22	11/3	51.010	13.583	191.560	0.0001
18.22<VLa
HPV 31	57/482	Ref.b	—	—	—
Negative	0/7	0	0	999	0.9866
0<VLa⩽0.50	2/7	2.416	0.490	11.910	0.2785
0.50<VLa⩽10.25	3/5	5.074	1.181	21.791	0.0290
10.25<VLa
HPV 18/45	54/473	Ref.b	—	—	—
Negative	2/10	1.752	0.374	8.205	0.4767
0<VLa⩽0.11	2/9	1.947	0.410	9.243	0.4021
0.11<VLa⩽3.40	4/9	3.893	1.160	13.068	0.0278
3.40<VLa
Random smear cohort
HPV 16	52/492	Ref.b	—	—	—
Negative	13/23	5.348	2.557	11.183	0.0001
0<VLc⩽0.49	18/18	9.462	4.637	19.304	0.0001
0.49<VLc⩽3.09	25/10	23.654	10.767	51.967	0.0001
3.09<VLc⩽21.96	31/5	58.662	21.866	151.377	0.0001
21.96<VLc
HPV 31	130/514	Ref.b	—	—	—
Negative	2/13	0.608	0.136	2.792	0.5163
0<VLc⩽1.29	3/10	1.186	0.322	4.372	0.7976
1.29<VLc⩽12.70	4/11	1.438	0.451	4.588	0.5397
12.70<VLc
HPV 18/45	111/492	Ref.b	—	—	—
Negative	9/19	2.100	0.925	4.764	0.0760
0<VLc⩽0.65	7/21	1.477	0.613	3.561	0.3846
0.65<VLc⩽2.65	12/16	3.324	1.530	7.225	0.0024
2.65<VLc

^aNormalised viral load (number of HPV genomes per human cell equivalent).

^bReference group.

^cMean normalised viral load (number of HPV genomes per human cell equivalent) based on all HPV-positive smears per individual.