Table 2. OS and DFS of randomised trials of chemotherapy with RT vs RT alone in locally advanced NPC.
| Author | Treatment arm | OS | DFS | Median F/U (mo) |
|---|---|---|---|---|
| Neoadjuvant chemotherapy+RT vs RT alone | ||||
| VUMCA (1996) | a | 3 yr – 60% | 3 yr – 52% *P<0.01 | 49 |
| b | 54% | 32% | ||
| Hareyama et al (2002) | a | 5 yr – 60% | 5 yr – 55% | 49 |
| b | 48% | 43% | ||
| Chua et al (1998) | a | 3 yr – 78% | 3 yr – 48% | 30 |
| b | 71% | 42% | ||
| Ma et al (2001) | a | 5 yr – 63% | 5 yr – 59% *P=0.05 | 62 |
| b | 56% | 49% | ||
| Chua et al (2004)a | a | 5 yr – 64% *P=0.029 | 5 yr – 51% *P=0.014 | 67 |
| b | 58% | 43% | ||
| Concurrent chemotherapy+RT vs RT alone | ||||
| Lin et al (2003) | a | 5 yr – 72% *P<0.01 | 5 yr – 72% *P<0.01 | 65 |
| b | 54% | 53% | ||
| Chan et al (2002, 2004) | a | N/A | 2 yr – 76% | 33 |
| b | N/A | 69% | ||
| a | 5 yr – 70% *P<0.05 | 5 yr – 60% | 65 | |
| b | 59% | 52% | ||
| Adjuvant chemotherapy+RT vs RT alone | ||||
| Rossi et al (1988) | a | 5 yr – 55% | 5 yr – 54% | 49.5 |
| b | 61% | 50% | ||
| Chi et al (2002) | a | 4 yr – 59% | 4 yr – 58% | 43 |
| b | 67% | 56% | ||
| Neoadjuvant and adjuvant chemotherapy+RT vs RT alone | ||||
| Chan et al (1995) | a | 2 yr – 80% | 2 yr – 68% | 28.5 |
| b | 81% | 72% | ||
| Concurrent and adjuvant chemotherapy+RT vs RT alone | ||||
| Al-Sarraf et al (1998, 2001) | a | 3 yr – 76% *P<0.001 | 3 yr – 66% *P<0.001 | 32.4 |
| b | 46% | 26% | ||
| a | 5 yr – 67% *P<0.001 | 5 yr – 58% *P<0.001 | 60 | |
| b | 37% | 29% | ||
| Wee et al (2004) | a | 2 yr – 85% *P=0.02 | 2 yr – 76% | N/A |
| b | 77% | 62% | ||
| Lee et al (2004) | a | 3 yr – 77% | 3 yr – 67% | 25 |
| b | 76% | 61% | ||
| Kwong et al (2004) | a1 | 3 yr – 89% | 3 yr – 70% | 32.5 |
| a2 | 84% | 69% | ||
| a3 | 71% | 54% | ||
| b | 83% | 61% | ||
*
Statistically significant result (P⩽0.05). a(a1, a2, a3)=combined therapy arm; b=radiotherapy alone arm; OS=overall survival; DFS=disease-free survival; NPC=nasopharyngeal carcinoma; RT=radiotherapy; N/A=not applicable; yr=year; mo=months.
a
This reference is an updated analysis of patients from Chua et al (1998) and Ma et al (2001).