Table 2. Dose limiting toxicities (DLTs) and occurrence of toxicities necessitating dose reduction or dose omission by the seven dose levels of gemcitabine tested.

Gemcitabine dose	Number of patients treated	Number of patients needed reduction or omission of at least one dose	Number of patients with a DLT
25 mg m−2 weekly	4	0	0
25 mg m−2 twice weekly	3	2	0
37.5 mg m−2 twice weekly	3	0	0
50 mg m−2 twice weekly	7	4	0
62.5 mg m−2 twice weekly	6	2	1
75 mg m−2 twice weekly	2	1	1