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. 2005 Mar 22;92(6):1110–1116. doi: 10.1038/sj.bjc.6602461

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Copyright © 2005 Cancer Research UK

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The effect of gefitinib on cancer cell proliferation under EGF stimulation was investigated in two cell lines (OCUT-2 and ACT-1). The number of cells was counted after 48 h following EGF stimulation. Although no stimulatory effect of EGF was displayed in OCUT-2 (A), which faintly expresses EGFR, a marked stimulatory effect of EGF on cell proliferation was displayed in the ACT-1 cell line (B), which overexpresses EGFR. A significant inhibitory effect of gefitinib on growth stimulation by EGF was recognised in a dose-dependent manner in ACT-1. The dose of gefitinib required to inhibit the effect of EGF stimulation was as low as 100 nM, and was as effective as EGF neutralisation.