Table 2. Haematological and nonhaematological toxicity by dose level.
| Dose level | No. of patients | No. of cycles | Haematological toxicities | Nonhaem. toxicities | Best responses |
|---|---|---|---|---|---|
| 1 | 3 | 15 | G2 neutropaenia | G1 Arthralagia | 1 PR |
| 2 | 4 | 12 | G3 anaemia | Allergic reaction to taxol | 1 MR |
| G3 thrombocytopaenia | |||||
| 3 | 2 | 3 | G3 neutropaenia | G2 Arth. | |
| 4 | 6 | 16 | G4 neutropaenia × 1; G3 neutropaenia × 1 | G2 Arth. | 1 MR |
| G3 thrombocytopaenia × 2; G3 anaemia × 1 | Allergy to taxol | ||||
| 5 | 3 | 5 | G2 neutropaenia | 1 SD | |
| 6 | 3 | 10 | G2 neutropaenia × 2 | 1 PR |
PR=partial response; MR=mixed response; SD=stable disease.