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. 2005 Mar 8;92(6):1006–1012. doi: 10.1038/sj.bjc.6602438

Table 4. Paclitaxel pharmacokinetic parameters.

Dose level Half-life (min) Clearance (ml min−1) Volume of distribution (litres) AUC (μg ml−1 min−1)
1 (150 mg m−2) 470, 522 364, 430 247, 324 632, 600
2 (150 mg m−2) 502, 383 652, 513 473, 283 359, 480
3 (150 mg m−2) 550, 412, 105a 779, 909, 505a 619, 540, 76a 385, 300, 523a
4 (175 mg m−2) 410±74 373±100 216±53 858±255
5 (200 mg m−2) 495, 198a 320, 717a 228, 205a 1162, 544a
6 (225 mg m−2) 298±87 363±120 152±63 1220±416
a

Data only to 8 h.