Table 3. ORs for breast cancer by tertiles of IGF-I, IGF-II and IGFBP-3 for postmenopausal women.

	Tertile 1	Tertile 2	Tertile 3	P for trend
IGF-I
Number of cases/controls	18/48	13/46	16/47
OR, crudea	1.00	0.76 (0.34–1.70)	0.90 (0.42–1.97)	0.80
OR, adjustedb	1.00	0.62 (0.25–1.56)	0.77 (0.34–1.74)	0.56
OR, adjustedc	1.00	0.60 (0.24–1.55)	0.73 (0.29–1.84)	0.52
IGF-II
Number of cases/controls	20/47	10/47	17/47
OR, crudea	1.00	0.52 (0.22–1.21)	0.83 (0.38–1.83)	0.64
OR, adjustedb	1.00	0.45 (0.19–1.20)	0.87 (0.37–2.05)	0.67
OR, adjustedc	1.00	0.43 (0.17–1.10)	0.81 (0.29–2.28)	0.63
IGFBP-3
Number of cases/controls	16/47	15/47	16/47
OR, crudea	1.00	0.94 (0.43–2.08)	1.00 (0.43–2.34)	1.00
OR, adjustedb	1.00	0.99 (0.43–2.27)	0.99 (0.40–2.46)	0.98
OR, adjustedd	1.00	1.06 (0.45–2.47)	1.14 (0.40–3.23)	0.81

OR=odds ratios; IGF=insulin-like growth factor; IGFBP=IGF-binding proteins.

^aCrude (matched for age at recruitment, date of blood collection, number of years postmenopausal or hysterectomy).

^bAdjusted for BMI, age at menarche and age at first birth.

^cAdjusted for BMI, age at menarche, age at first birth and IGFBP-3.

^dAdjusted for BMI, age at menarche, age at first birth and IGF-I.