Table 4. Multivariate regression analyses in predicting survival of NSCLC patients.

	Stage I			Stage II, Stage III
Biological markers	Hazard ratio	95% CI	P-value	Hazard ratio	95% CI	P-value
Ki-67 index	1.75	0.73–4.21	0.20	2.04	1.09–3.80	0.02
IMD	3.34	1.30–7.86	<0.01	1.38	0.75–2.54	0.28
TS status	1.31	0.57–2.98	0.51	2.43	1.34–4.42	<0.01
VEGF-A status	2.37	1.07–5.24	0.03	1.27	0.69–2.35	0.43
VEGF-C status	2.10	1.01–4.37	0.03	0.94	0.54–1.64	0.83
E-cadherin status	2.30	1.03–5.16	0.03	1.50	0.85–2.63	0.15

NSCLC=non-small-cell lung cancer; CI=confidence interval; IMD=intratumoral microvessel density; TS=thymidylate synthase; VEGF=vascular endothelial growth factor; MVP=mitomycin/vinblastin/cisplatin; E-cadherin=epithelial cadherin.