Table 3. Incidence of degenerating myelinated fibres in rats treated with PTX or NK105.
| Treatment | n a |
Degenerating myelinated nerve fibre scoreb
|
||||
|---|---|---|---|---|---|---|
| − | +/− | + | ++ | +++ | ||
| Control (vehicle) | 13 | 12 | 1 | |||
| PTXc | 10 | 1 | 4 | 5 | ||
| NK105d | 14 | 8 | 2 | 4 | ||
PTX=paclitaxel.
Vehicle, NK105 or PTX was administered i.v. at a weekly dose of 7.5 mg kg−1 for 6 consecutive weeks to female rats.
a
Total number of animals accounted for that experimental condition.
b
Degenerating myelinated fibre score was defined as follows: −, no degenerative changes; +/−, very slight degree of the degenerative changes (scattered, single fibres affected); +, slight degree of degenerative changes (scattered small groups of degenerative myelinated fibers); ++, moderate degree of degenerative changes (disseminated degenerative myelinated fibers); +++, marked degree of degenerative changes (confluent groups of affected fibres).
c
P<0.001 vs vehicle-treated animals.
d
P<0.001 vs PTX-treated animals.