Table 1. Expression of VEGF, VEGFR1 and VEGFR2 on osteoclasts present in breast metastases to bone.
| Patient | Osteoclasts present | VEGF | VEGFR1 | VEGFR2 |
|---|---|---|---|---|
| 1 | + | ++ | ++ | ++ |
| 2 | + | ++ | ++ | ++ |
| 3 | − | − | − | − |
| 4 | + | ++ | ++ | ++ |
| 5 | + | ++ | + | ++ |
| 6 | + | +++ | 0 | + |
| 7 | + | +++ | + | ++ |
| 8 | + | ++ | 0 | ++ |
| 9 | − | − | − | − |
| 10 | + | ++ | + | ++ |
| 11 | + | ++ | ++ | ++ |
| 12 | + | ++ | ++ | + |
| 13 | + | +++ | ++ | ++ |
| 14 | + | ++ | ++ | +++ |
| 15 | + | ++ | ++ | ++ |
| 16 | − | − | − | − |
| 17 | + | ++ | ++ | ++ |
(−)=no osteoclasts present; (0)=negative staining; (+)=weak staining; (++)=moderate staining; (+++)=strong staining; VEGF=vascular endothelial growth factor; VEGFR1/2=vascular endothelial growth factor receptor 1/2.