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. 2005 Apr 5;92(8):1421–1429. doi: 10.1038/sj.bjc.6602526

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Copyright © 2005 Cancer Research UK

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Therapeutic vaccination of tumour-bearing animals. BALB/c mice were inoculated with Renca-lacZ/ErbB2 tumour cells by s.c. injection into each flank. When tumours were palpable, animals were treated twice by s.c. injection of Tc-ErbB2/Th-HA liposomes (○), Tc-ErbB2 liposomes (•), or liposomal carrier as a control (⧫) into the vicinity of each tumour. (A) Tumour growth was followed by caliper measurements and mean tumour volumes were calculated. As indicated by the asterisk, due to tumour growth one of the Tc-ErbB2/Th-HA- and two of the Tc-ErbB2-treated animals had to be killed on days 43 and 51, respectively. Subsequently, mean tumour volumes in these groups were calculated from the remaining animals. In the control group, all mice were killed due to tumour growth latest until day 43. (B) Course of the disease in mice from the experiment shown in (A). In addition to the animals that had completely rejected their tumours and were tumour free, in each group treated with Tc-ErbB2/Th-HA or Tc-ErbB2 liposomes one animal developed only small tumours until day 86 when the experiment was terminated. All other tumour-bearing mice were killed latest when tumour size reached 0.8 cm³ to avoid suffering of the animals.