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. 2005 Mar 22;92(8):1561–1573. doi: 10.1038/sj.bjc.6602480

Table 3. Upregulated genes expressed at least 10-fold higher in NEC compared with USPC.

Probe set Gene symbol SAM P of WRS Ratio NEC/USPC Title
774_g_at MYH11 17.611 0.0027 1014.968759 ‘Myosin, heavy polypeptide 11, smooth muscle’
773_at MYH11 14.265 0.0027 968.0223497 ‘Myosin, heavy polypeptide 11, smooth muscle’
32582_at MYH11 11.277 0.0027 212.2458648 ‘Myosin, heavy polypeptide 11, smooth muscle’
36681_at APOD 11.714 0.0027 137.3140116 Apolipoprotein D
1501_at IGF1 8.321 0.0027 128.0651104 Insulin-like growth factor 1 (somatomedin C)
39325_at EBAF 8.177 0.0027 123.064609 ‘Endometrial bleeding associated factor)’
767_at 12.707 0.0027 119.5409103
40398_s_at MEOX2 10.182 0.0027 114.9489897 Mesenchyme homeo box 2
40776_at DES 9.738 0.0027 109.416397 Desmin
1197_at ACTG2 5.861 0.0027 96.65715109 ‘Actin, gamma 2, smooth muscle, enteric’
36627_at SPARCL1 7.724 0.0027 93.89302842 ‘SPARC-like 1 (mast9, hevin)’
37407_s_at MYH11 11.893 0.0027 88.70362054 ‘Myosin, heavy polypeptide 11, smooth muscle’
39673_i_at ECM2 8.459 0.0027 82.52353674 ‘Extracellular matrix protein 2, female organ and adipocyte specific’
39701_at PEG3 7.645 0.0027 73.87997223 Paternally expressed gene 3
39066_at MFAP4 9.383 0.0027 68.84723295 Microfibrillar-associated protein 4
38737_at IGF1 6.341 0.0027 65.13666715 Insulin-like growth factor 1 (somatomedin C)
35730_at ADH1B 9.759 0.0027 64.94146631 ‘Alcohol dehydrogenase IB (class I), beta polypeptide’
41124_r_at ENPP2 7.007 0.0027 53.43118221 Ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)
36749_at CPA3 9.096 0.0027 53.07347991 Carboxypeptidase A3 (mast cell)
39616_at PTGER3 10.188 0.0027 52.65326101 Prostaglandin E receptor 3 (subtype EP3)
33440_at TCF8 7.220 0.0027 49.54168001 Transcription factor 8
32666_at CXCL12 7.168 0.0027 49.2359637 Chemokine (C–X–C motif) ligand 12
38734_at PLN 9.182 0.0027 47.86730799 Phospholamban
34203_at CNN1 5.051 0.0027 47.0209722 ‘Calponin 1, basic, smooth muscle’
37576_at PCP4 12.468 0.0027 45.45542357 Purkinje cell protein 4
36834_at MOXD1 9.736 0.0027 44.20917891 ‘Monooxygenase, DBH-like 1’
37247_at TCF21 9.810 0.0027 42.40051895 Transcription factor 21
37701_at RGS2 7.408 0.0027 42.29038464 ‘Regulator of G-protein signalling 2, 24 kDa’
779_at COL4A6 5.840 0.0027 41.96325597 ‘Collagen, type IV, alpha 6’
37394_at C7 9.835 0.0027 40.72326307 Complement component 7
36533_at PTGIS 6.097 0.0027 39.10052985 Prostaglandin I2 (prostacyclin) synthase
32689_s_at 6.178 0.0027 36.96897988
32905_s_at TPSB2 6.873 0.0027 36.85974711 Tryptase beta 2
33240_at SEMACAP3 4.814 0.0027 36.54583796 Likely ortholog of mouse semaF cytoplasmic domain associated protein 3
1466_s_at FGF7 8.628 0.0027 35.60413415 Fibroblast growth factor 7
32686_at PTGER3 7.397 0.0027 35.31357002 Prostaglandin E receptor 3 (subtype EP3)
39690_at ALP 6.951 0.0027 33.76045029 Alpha-actinin-2-associated LIM protein
38427_at COL15A1 7.196 0.0027 32.85391153 ‘Collagen, type XV, alpha 1’
39939_at COL4A6 6.846 0.0027 32.53815505 ‘Collagen, type IV, alpha 6’
37630_at NRLN1 5.896 0.0027 31.03030255 Neuralin 1
35717_at ABCA8 7.587 0.0027 30.63819827 ‘ATP-binding cassette, subfamily A, member 8’
1709_g_at MAPK10 6.522 0.0027 30.54331363 Mitogen-activated protein kinase 10
35679_s_at DPP6 5.899 0.0027 30.33959319 Dipeptidylpeptidase 6
35740_at EMILIN1 7.445 0.0027 29.45261895 Elastin microfibril interfacer 1
41123_s_at ENPP2 6.597 0.0027 29.29614059 Ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)
755_at ITPR1 8.211 0.0027 29.02124207 ‘Inositol 1,4,5-triphosphate receptor, type 1’
32847_at MYLK 5.388 0.0027 28.22518538 ‘Myosin, light polypeptide kinase’
38001_at CACNA1C 5.740 0.0027 27.31347302 ‘Calcium channel, alpha 1C subunit’
37279_at GEM 9.925 0.0027 26.56613192 GTP-binding protein overexpressed in skeletal muscle
36396_at 5.901 0.0027 26.32457357 Homo sapiens mRNA; cDNA DKFZp586N2020 (from clone DKFZp586N2020)
41137_at PPP1R12B 12.043 0.0027 25.97089935 ‘Protein phosphatase 1, regulatory subunit 12B’
41405_at SFRP4 10.077 0.0027 23.90433923 Secreted frizzled-related protein 4
40775_at ITM2A 6.152 0.0027 23.83083993 Integral membrane protein 2A
38059_g_at DPT 6.508 0.0027 23.76376781 Dermatopontin
41504_s_at MAF 5.331 0.0027 23.65323618 v-maf
1596_g_at TEK 4.542 0.0027 23.37422615 ‘TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)’
914_g_at ERG 6.105 0.0027 22.63829292 v-ets erythroblastosis virus E26 oncogene like
34283_at 5.390 0.0041 22.19917455 Homo sapiens, clone IMAGE:4791553, mRNA’
34388_at COL14A1 9.452 0.0027 21.48165459 ‘Collagen, type XIV, alpha 1 (undulin)’
38994_at SOCS2 6.600 0.0027 21.47663968 Suppressor of cytokine signaling 2
36065_at LDB2 5.790 0.0027 21.19321308 LIM domain binding 2
40230_at FRZB 5.962 0.0027 21.00467856 Frizzled-related protein
33790_at CCL15 9.017 0.0027 20.5510028 Chemokine (C–C motif) ligand 15
33890_at RGS5 7.347 0.0027 20.2203337 Regulator of G-protein signalling 5
36513_at MAGP2 4.385 0.0041 20.10734871 Microfibril-associated glycoprotein-2
32526_at JAM3 6.129 0.0027 19.89641568 Junctional adhesion molecule 3
32687_s_at PTGER3 5.902 0.0027 19.7194642 Prostaglandin E receptor 3 (subtype EP3)
35638_at CBFA2T1 10.470 0.0027 19.57233853 ‘Core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related’
34637_f_at ADH1A 6.291 0.0027 19.20847669 ‘Alcohol dehydrogenase 1A (class I)’
34675_at SBLF 5.400 0.0027 19.04463285 Stoned B-like factor
38351_at 5.899 0.0026 18.69131208 Homo sapiens mRNA; cDNA DKFZp586L0120 (from clone DKFZp586L0120)
1182_at PLCL1 4.047 0.0027 18.50958764 Phospholipase C-like 1
39681_at ZNF145 6.266 0.0027 18.41823634 ‘Zinc-finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)’
1708_at MAPK10 6.336 0.0027 18.31250756 Mitogen-activated protein kinase 10
37765_at LMOD1 7.586 0.0027 18.11624265 Leiomodin 1 (smooth muscle)
1678_g_at IGFBP5 4.237 0.0041 17.88349387 Insulin-like growth factor binding protein 5
35358_at TENC1 9.243 0.0027 17.68277053 Tensin-like C1 domain-containing phosphatase
33442_at KIAA0367 6.830 0.0027 17.58195512 KIAA0367 protein
37249_at PDE8B 5.035 0.0027 17.25176904 Phosphodiesterase 8B
33834_at CXCL12 7.736 0.0027 17.10893345 Chemokine (C–X–C motif) ligand 12 (stromal cell-derived factor 1)
35324_at SLIT3 5.157 0.0027 17.08441711 Slit homolog 3 (Drosophila)
37015_at ALDH1A1 4.941 0.0027 16.83181709 ‘Aldehyde dehydrogenase 1 family, member A1’
39266_at 6.237 0.0027 16.80733058 Homo sapiens clone 24405 mRNA sequence
33462_at GPR105 4.907 0.0027 16.49634139 G protein-coupled receptor 105
32488_at COL3A1 3.928 0.0027 16.44993439 ‘Collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant)’
483_g_at CDH13 3.755 0.0027 16.43857351 ‘Cadherin 13, H-cadherin (heart)’
38026_at FBLN1 5.350 0.0027 16.06497318 Fibulin 1
1909_at BCL2 7.356 0.0027 16.01160367 B-cell CLL/lymphoma 2
36245_at HTR2B 4.698 0.0027 15.77119379 5-Hydroxytryptamine (serotonin) receptor 2B
32057_at LRRC17 5.470 0.0027 15.6891271 Leucine-rich repeat containing 17
39544_at DMN 5.361 0.0027 15.66465434 Desmuslin
37112_at C6orf32 4.720 0.0027 15.65975413 Chromosome 6 open reading frame 32
36733_at FLJ32389 4.442 0.0027 15.64273348 Hypothetical protein FLJ32389
1319_at DDR2 5.400 0.0027 15.5817123 ‘Discoidin domain receptor family, member 2’
38057_at DPT 8.479 0.0027 15.51358362 Dermatopontin
40358_at GLI3 6.650 0.0027 15.11249492 GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome)
38627_at HLF 4.947 0.0027 14.89249894 Hepatic leukemia factor
1731_at PDGFRA 7.050 0.0027 14.84422948 ‘Platelet-derived growth factor receptor, alpha polypeptide’
31897_at DOC1 4.664 0.0027 14.80084961 Downregulated in ovarian cancer 1
2073_s_at CDH13 5.076 0.0027 14.79118507 ‘Cadherin 13, H-cadherin (heart)’
38577_at 7.283 0.0027 14.78670234 ‘Clone DT1P1B6 mRNA, CAG repeat region’
38004_at CSPG4 6.072 0.0027 14.40637488 Chondroitin sulphate proteoglycan 4
32109_at FXYD1 7.333 0.0027 14.33463902 Phospholemman
34853_at FLRT2 9.834 0.0027 14.33080432 Fibronectin leucine-rich transmembrane protein 2
38298_at KCNMB1 7.046 0.0027 14.25816751 ‘Potassium large-conductance calcium-activated channel, subfamily M, beta member 1’
41245_at GDF10 6.643 0.0027 14.21467179 Growth differentiation factor 10
38322_at GAGEC1 6.215 0.0027 14.10508119 ‘G antigen, family C, 1’
1198_at EDNRB 4.899 0.0027 14.08196951 Endothelin receptor type B
41505_r_at MAF 4.528 0.0027 14.0059518 v-maf
36976_at CDH11 3.692 0.0027 14.00329993 ‘Cadherin 11, type 2, OB-cadherin (osteoblast)’
32688_at PTGER3 4.998 0.0027 13.68791213 Prostaglandin E receptor 3 (subtype EP3)
1575_at ABCB1 6.210 0.0027 13.64196645 ‘ATP-binding cassette, subfamily B’
32778_at ITPR1 4.914 0.0027 13.60359986 ‘Inositol 1,4,5-triphosphate receptor, type 1’
40737_at KCNMA1 5.642 0.0027 13.60011778 ‘potassium large-conductance calcium-activated channel, subfamily M, alpha member 1’
36569_at TNA 11.512 0.0027 13.14186685 Tetranectin (plasminogen-binding protein)
1897_at TGFBR3 4.922 0.0041 12.99722509 ‘Transforming growth factor, beta receptor III (betaglycan, 300 kDa)’
2087_s_at CDH11 4.345 0.0027 12.96131894 ‘Cadherin 11, type 2, OB-cadherin (osteoblast)’
34820_at PTN 4.413 0.0041 12.94626537 ‘Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)’
743_at NAP1L3 7.859 0.0027 12.91061134 Nucleosome assembly protein 1-like 3
1507_s_at EDNRA 4.319 0.0041 12.88466839 Endothelin receptor type A
38995_at CLDN5 12.156 0.0027 12.86636376 Claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)
1147_at 7.084 0.0027 12.69931721
1954_at KDR 6.077 0.0027 12.6174344 Kinase insert domain receptor (a type III receptor tyrosine kinase)
38786_at 5.676 0.0027 12.61170471 Homo sapiens mRNA full-length insert cDNA clone EUROIMAGE 248114
40757_at GZMA 4.575 0.0041 12.56281091 ‘Granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)’
36695_at na 5.776 0.0027 12.53905775 Similar to hypothetical protein 6720478C22
32052_at HBB 5.107 0.0063 12.52262761 ‘Haemoglobin, beta’
37446_at GASP 8.227 0.0027 12.39360585 G protein-coupled receptor-associated protein
38038_at LUM 4.462 0.0027 12.34757673 Lumican
32889_at RPIB9 6.337 0.0027 12.34540513 Rap2-binding protein 9
35234_at RECK 4.476 0.0027 12.33793353 Reversion-inducing-cysteine-rich protein
661_at GAS1 4.648 0.0027 12.32556384 Growth arrest-specific 1
41195_at LPP 6.292 0.0027 12.26636801 LIM domain containing preferred translocation partner in lipoma
32664_at RNASE4 6.395 0.0027 11.89680804 ‘Ribonuclease, RNase A family, 4’
39038_at FBLN5 4.325 0.0027 11.89440528 Fibulin 5
40693_at KCNB1 4.952 0.0041 11.84773944 ‘Potassium voltage-gated channel, Shab-related subfamily, member 1’
38052_at F13A1 5.346 0.0027 11.69181717 ‘Coagulation factor XIII, A1 polypeptide’
35220_at ENPEP 4.200 0.0027 11.66308093 Glutamyl aminopeptidase (aminopeptidase A)
37512_at RODH 5.112 0.0027 11.65031202 3-Hydroxysteroid epimerase
103_at THBS4 5.114 0.0027 11.6063075 Thrombospondin 4
36156_at AQP1 6.927 0.0027 11.6016663 ‘Aquaporin 1’
39593_at FGL2 5.176 0.0027 11.38223584 Fibrinogen-like 2
33248_at HOXA11 6.555 0.0027 11.34828098 Homeo box A11
41420_at IGFBP5 4.166 0.0041 11.32365037 Insulin-like growth factor binding protein 5
35644_at HEPH 6.666 0.0027 11.26324425 Hephaestin
39646_at CACNB2 4.719 0.0027 11.25017414 ‘Calcium channel, voltage-dependent, beta 2 subunit’
35333_r_at DVS27 4.403 0.0027 11.23759398 DVS27-related protein
33182_at 4.990 0.0027 11.20258783 Homo sapiens mRNA full-length insert cDNA clone EUROIMAGE 1630957
34303_at FLJ90798 4.909 0.0027 11.10458088 Hypothetical protein FLJ90798
33756_at AOC3 5.186 0.0027 11.09776026 ‘Amine oxidase, copper containing 3 (vascular adhesion protein 1)’
37710_at MEF2C 7.485 0.0027 11.03832245 ‘MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)’
35680_r_at DPP6 3.783 0.0027 10.88151987 Dipeptidylpeptidase 6
40126_at 4.620 0.0027 10.87424764
31831_at SMTN 5.712 0.0027 10.84917408 Smoothelin
234_s_at PTN 5.660 0.0041 10.803161 ‘Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)’
36939_at GPM6A 4.981 0.0027 10.76644676 Glycoprotein M6A
41158_at PLP1 4.879 0.0027 10.76462278 ‘Proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)’
41839_at GAS1 4.401 0.0027 10.75375673 Growth arrest-specific 1
1186_at GDF10 4.165 0.0063 10.74677086 Growth differentiation factor 10
35404_at TACR2 4.416 0.0063 10.67366905 Tachykinin receptor 2
160023_at WNT2 5.424 0.0027 10.67077677 Wingless-type MMTV integration site family member 2
34561_at MS4A2 6.380 0.0027 10.6336763 ‘Membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)’
36280_at GZMK 4.739 0.0027 10.5607572 ‘Granzyme K’
35668_at RAMP1 3.430 0.0027 10.4886967 Receptor (calcitonin) activity modifying protein 1
32521_at SFRP1 4.488 0.0027 10.43051698 Secreted frizzled-related protein 1
1975_s_at IGF1 7.381 0.0027 10.34307322 Insulin-like growth factor 1 (somatomedin C)
37671_at LAMA4 5.094 0.0027 10.34084543 ‘Laminin, alpha 4’
40013_at CLIC2 5.388 0.0027 10.2736905 Chloride intracellular channel 2
32782_r_at BPAG1 4.597 0.0027 10.2197061 ‘Bullous pemphigoid antigen 1, 230/240 kDa’
36918_at GUCY1A3 4.344 0.0027 10.18606373 ‘Guanylate cyclase 1, soluble, alpha 3’
32239_at MATN2 6.197 0.0027 10.14895891 Matrilin 2
36503_at CCL21 6.812 0.0027 10.09354903 Chemokine (C–C motif) ligand 21
38508_s_at TNXB 8.826 0.0027 10.0794719 Tenascin XB
35146_at TGFB1I1 5.562 0.0027 10.0680837 Transforming growth factor beta 1
38653_at PMP22 6.085 0.0027 10.04665889 Peripheral myelin protein 22
342_at ENPP1 5.008 0.0041 10.0434301 Ectonucleotide pyrophosphatase/phosphodiesterase
32826_at ENTPD1 6.423 0.0027 10.01186286 Ectonucleoside triphosphate diphosphohydrolase 1
40318_at DNCI1 3.348 0.0063 10.00454416 ‘Dynein, cytoplasmic, intermediate polypeptide 1’