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. 2005 Apr 19;92(9):1696–1701. doi: 10.1038/sj.bjc.6602522

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Copyright © 2005 Cancer Research UK

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RT112-TP treated with thymidine and hypoxia secrete significantly more VEGF than cells receiving either treatment alone. Triplicate wells of RT112-TP were exposed to one of four treatments (0 μM thymidine+21% oxygen; 200 μM thymidine+21% oxygen; 0 μM thymidine+0.1% oxygen; 200 μM thymidine+0.1% oxygen). Mean VEGF production (+one standard error), expressed as picogram VEGF/million cells/16 h of culture is shown. As expected, both thymidine and hypoxia alone increased VEGF secretion. However, RT112-TP treated with both thymidine and hypoxia produced significantly more VEGF than those treated with thymidine alone (P=0.0495, Kruskall–Wallis analysis), and also secreted significantly more VEGF than RT112-TP exposed to hypoxia alone (P=0.0495, Kruskall–Wallis analysis). (^*=significant difference by Kruskall–Wallis analysis).