Box 2. Effects of antiangiogenic and antivascular therapeutics.

Antiangiogenic therapy

• Inhibition of growth factor support of neovasculature.

• Reduced permeability.

• Reduced perfusion.

• Reduced blood volume.

Antivascular therapy

• Collapse of proliferating vasculature.

• Possible collapse of mature tumour vasculature.

• Loss of permeable vasculature.

• Reduced perfusion/flow.

• Reduced blood volume.

• Reduced tortuosity.