Table 3. Changes of hormone levels between first and third trimesters by racial groups and the significance of the changes between racial groupsa.

	White mothers (n=150)		Black mothers (n=150)		White mothers vs black mothers
Hormones	Meanb	P-value	Meanb	P-value	P-valuec
Alphafetoprotein	3.3	<0.01	3.0	<0.01	<0.01
Total estradiol	2.1	<0.01	2.0	<0.01	0.11
Free estradiol	1.6	<0.01	1.5	<0.01	0.02
Free and albumin-bound estradiol	1.6	<0.01	1.5	<0.01	0.02
Total estriol	2.7	<0.01	2.6	<0.01	0.30
Total testosterone	0.2	<0.01	0.3	<0.01	0.36
Free testosterone	−0.5	<0.01	−0.4	<0.01	0.36
Free and albumin-bound testosterone	−0.5	<0.01	−0.4	<0.01	0.36
Sex hormone binding globulin	0.8	<0.01	0.8	<0.01	0.98
Ratios
Total estradiol/total testosterone	1.9	<0.01	1.7	<0.01	0.01
Free estradiol/free testosterone	2.1	<0.01	1.9	<0.01	0.01
Free and albumin-bound estradiol/free albumin-bound testosterone	2.1	<0.01	1.9	<0.01	0.01

^aMatched analyses.

^bMeans of the differences of the natural logarithm of hormone levels.

^cAdjusted for gestational age at blood draw (continuous) and maternal weight at pre-pregnancy and delivery (continuous).