Table 1. ADPM-mediated cytotoxicitya,b.
|
ADPM01
|
ADPM06
|
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|---|---|---|---|---|---|---|---|
| Cell line | Tissue origin | EC50 (M) (dark) | EC50 (M) (8 J cm−2) | EC50 (M) (16 J cm−2) | EC50 (M) (dark) | EC50 (M) (8 J cm−2) | EC50 (M) (16 J cm−2) |
| HeLa | Cervix | 2.7 × 10−5 (±1.0) | 2.8 × 10−6 (±0.7) | 9.2 × 10−7 (±1.0) | >10−4 | 6.3 × 10−8 (±2.0) | 4.1 × 10−8 (±3.0) |
| MRC-5 | Lung | >10−4 | 3.1 × 10−6 (±3.0) | 5.0 × 10−7 (±1.0) | >10−4 | 3.7 × 10−8 (±0.3) | 1.4 × 10−8 (±0.1) |
| HT-1080 | Connective tissue from hip socket | >10−4 | 3.4 × 10−5 (±0.9) | 2.2 × 10−5 (±4.0) | 4.4 × 10−6 (±4.0) | 7.9 × 10−8 (±1.0) | 3.7 × 10−8 (±5.0) |
| T47-D | Breast | >10−4 | 5.6 × 10−6 (±0.5) | 5.3 × 10−6 (±1.9) | >10−4 | 1.6 × 10−6 (±0.8) | 6.3 × 10−7 (±3.3) |
| MCF-7 | Breast | >10−4 | 3.4 × 10−6 (±1.7) | 1.9 × 10−6 (±4.7) | >10−4 | 1.2 × 10−7 (±3.1) | 7.5 × 10−8 (±2.1) |
| MDA-MB-231 | Breast | 1.2 × 10−5 (±0.5) | 5.6 × 10−6 (±3.0) | 2.6 × 10−7 (±0.5) | >10−4 | 1.4 × 10−7 (±1.9) | 7.5 × 10−8 (±1.2) |
| SW480 | Colon | >10−4 | 7.6 × 10−6 (±0.9) | 8.0 × 10−7 (±0.7) | >10−4 | 5.4 × 10−6 (±1.0) | 4.2 × 10−8 (±0.2) |
| SW620 | Colon | >10−4 | 5.6 × 10−6 (±0.7) | 2.8 × 10−6 (±0.7) | >10−4 | 7.5 × 10−8 (±2.9) | 6.0 × 10−8 (±1.1) |
| A2780 | Ovary | >10−4 | 5.1 × 10−6 (±5.1) | 4.5 × 10−6 (±1.2) | >10−4 | 1.0 × 10−7 (±0.7) | 3.5 × 10−8 (±4.2) |
| A2780cp70 | Ovary | >10−4 | 6.8 × 10−6 (±3.2) | 2.8 × 10−6 (±2.8) | >10−4 | 6.2 × 10−8 (±3.1) | 2.7 × 10−8 (±1.2) |
a
Cytotoxic potential of compounds assessed in vitro using a standard MTT assay. Cells were incubated with PDT agent for 3 h prior to irradiation with 0, 8 or 16 J cm−2.
b
Mean and standard deviation (in parenthesis) of triplicate determinations.