Table 2. Effect of hypoxia on ADPM-mediated cytotoxicitya.

		ADPM01			ADPM06
	Oxygen conditions	EC50 (M) (dark)	EC50 (M) (8 J cm−2)	EC50 (M) (16 J cm−2)	EC50 (M) (dark)	EC50 (M) (8 J cm−2)	EC50 (M) (16 J cm−2)
HeLa	Normoxiab	2.7 × 10−5 (±1.0)	2.8 × 10−6 (±0.7)	9.2 × 10−7 (±1.0)	>10−4	6.3 × 10−8 (±2.0)	4.1 × 10−8 (±3.0)
	Hypoxiac	>10−4	>10−4	>10−4	>10−4	6.1 × 10−6 (±2.2)	1.5 × 10−6 (±2.0)
MRC5	Normoxiab	>10−4	3.1 × 10−6 (±3.0)	5.0 × 10−7 (±1.0)	>10−4	3.7 × 10−8 (±0.3)	1.4 × 10−8 (±0.1)
	Hypoxiac	>10−4	>10−4	>10−4	>10−4	7.1 × 10−6 (±2.6)	1.6 × 10−6 (±1.8)

^aCells were grown under either normoxic or hypoxic conditions prior to PDT, with cell viability assessed by a standard MTT assay.

^bNormoxia=21% oxygen.

^cHypoxia=1% oxygen.