Table 3. ORsa showing the effect of HPV positivity at baseline, with cases stratified jointly by grade of diagnosis and time to diagnosis.
|
Time to diagnosis
|
|||||
|---|---|---|---|---|---|
| ⩾8 years (n=209) | 4–8 years (n=205) | <4 years (n=150) | All cases (n=564) | Linear trendb | |
| Grade of diagnosis | |||||
| CIN 2 (n=167) | 0.93 (0.44–1.99) | 1.56 (0.81–3.03) | 2.30 (1.23–4.31) | 1.55 (1.01–2.38) | P=0.022 |
| (9/55) | (13/57) | (16/55) | (38/167) | ||
| CIN 3 (n=346) | 1.55 (0.97–2.47) | 1.90 (1.21–2.98) | 3.82 (2.30–6.33) | 2.13 (1.54–2.95) | P<0.001 |
| (31/132) | (35/133) | (32/81) | (98/346) | ||
| Cancer (n=51) | 2.83 (1.11–7.23) | 5.65 (1.95–16.3) | 1.38 (0.28–6.81) | 3.32 (1.71–6.48) | P<0.001 |
| (7/22) | (7/15) | (2/14) | (16/51) | ||
| All cases (n=564) | 1.47 (0.99–2.20) | 1.97 (1.34–2.89) | 2.97 (1.96–4.50) | — | P<0.001 |
| (47/209) | (55/205) | (50/150) | |||
| Linear trendc | P=0.029 | P<0.001 | P<0.001 | P<0.001 | |
OR=odds ratio; HPV=human papillomavirus; CIN=cervical intraepithelial neoplasia.
Numbers in cells represent the OR for the case group compared with controls (and 95% CI), the numbers within parentheses underneath are the number of HPV+ women/total number of women in case group.
a
All ORs are adjusted for age using logistic regression.
b
The linear trend was calculated by fitting time to diagnosis as the outcome variable in an ordinal logistic regression model (with controls comprising the baseline group).
c
The linear trend was calculated by fitting grade of lesion as the outcome variable in an ordinal logistic regression model (with controls comprising the baseline group).