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. 2005 May 31;92(Suppl 1):S21–S27. doi: 10.1038/sj.bjc.6602605

Table 1. Activity profile of molecular-targeted agents.

Single target Multiple target
Bevacizumab (anti-VEGF MAb) BAY 43-9006 (Raf-1, VEGFR-2 and -3, and PDGFR-β)
 
Cetuximab (EGFR MAb) PTK787 (VEGFR-1, -2 and -3, PDGFR-β and c-Kit)
 
IMC-1121b (VEGFR-2 MAb) SU11248 (VEGFR-1, -2 and -3, Flt-3, PDGFR, c-Kit and CSF-1)
  ZD6474 (VEGFR and EGFR)
  AEE-788 (VEGFR, EGFR, erb)
  AMG 706 (VEGFR, PDGFR, c-Kit and Ret)