Table 3. Therapeutic management over time.

	1982–85		1986–89		1990–93		1994–97
Period	No.	%	No.	%	No.	%	No.	%	P
Resectable disease
Radiotherapya	44	24.4	35	17.9	26	12.7	23	11.4	0.0023
Surgerya	60	33.3	99	50.5	108	52.9	112	55.4	<0.0001
Chemotherapy	2	1.1	2	1.0	5	2.5	6	3.0	0.4290
Surgery+radiotherapy	31	17.2	41	20.9	34	16.7	24	11.9	0.1149
Surgery+chemotherapy	11	6.1	5	2.6	6	2.9	8	4.0	0.2777
Chemotherapy+radiotherapy	13	7.2	1	0.5	2	1.0	8	4.0	0.0004
Surgery+radio+chemotherapy	8	4.4	3	1.5	11	5.4	10	5.0	0.2043
Supportive care	11	6.1	10	5.1	12	5.9	11	5.4	0.9745
Locally advanced disease
Radiotherapya	28	53.8	49	70.0	39	40.6	12	12.9	<0.0001
Chemotherapy	7	13.5	3	4.3	12	12.5	11	11.8	0.2720
Chemotherapy+surgery	0	0.0	0	0.0	0	0.0	2	2.2	0.2419
Chemo+radiotherapya	11	21.2	9	12.9	29	30.2	55	59.1	<0.0001
Chemo+surgery+radiotherapy	0	0.0	3	4.3	6	6.3	4	4.3	0.3247
Supportive care	6	11.5	6	8.6	10	10.4	9	9.7	0.9552
Metastatic disease
Radiotherapya	28	31.1	30	24.6	17	11.5	8	4.6	<0.0001
Chemotherapya	24	26.7	32	26.2	64	43.2	113	65.3	<0.0001
Chemotherapy+surgery	0	0.0	1	0.8	1	0.7	2	1.2	0.9155
Chemo+radiotherapya	17	18.9	4	3.3	15	10.1	10	5.8	0.0003
Surgery	0	0.0	0	0.0	1	0.7	0	0.0	0.6754
Chemo+radiotherapy+surgery	0	0.0	0	0.0	0	0.0	1	0.6	0.9999
Supportive care	21	23.3	55	45.1	50	33.8	39	22.5	0.0002

^aLinear trend significant