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. Author manuscript; available in PMC: 2009 Apr 1.
Published in final edited form as: Dev Biol. 2008 Jan 18;316(1):87–99. doi: 10.1016/j.ydbio.2008.01.006

Fig. 7. DAPT treatment down-regulated Hesr1/2 expression, and inhibited sensory epithelium development.

Fig. 7

A–C: Explant cultures treated with DAPT for 6 days in vitro (see Fig. 7A), and stained with anti-Myo6 (A), Prox1 (B) and Sox2 (C). Basal end is to the right the apex is to the left. D: Hesr1 and Hesr2 mRNA levels of cochleas treated with DAPT (magenta bars) for 12 or 24 hours were compared with control cultures (no DAPT, blue bars). Error bars indicate standard deviations of the means¨ Asterisk indicates P< 0.05, double asterisk indicate P< 0.005 compared to the control with a Student's T-test. The number of explants (N) is indicated above each panel. Scale bar= 100 µm.