Table 3.

Inhibition of Replication of EBV with Fluoromethyl Methylenecyclopropane Nucleoside Analogues^a

Compound	EC50/CC50 (µM)b	Selectivity Index
2b	2.5/>100c	>40
5a	6.8/>213	>31.3
5b	8.0/>199	>24.9
6a	167/>209d	>1.25
6b	29.1/>199e	>6.8
15a	0.5/55.7	111
15b	7.5/59.7	8
16a	3.4/53.6	15.8
16b	3.2/64.1	20

^aAkata cells, DNA hybridization assay. For details see Experimental. Acyclovir as a control had EC₅₀ 1.7 µM.

^bResults for analogues 5a - 6b were taken from from ref.7 (DNA hybridization assay in Daudi cells).

^cData from ref.19

^dEC₅₀ 2.3 µM in viral capsid immunofluorescence (VCA) ELISA and 3.6 µM in H-1 cells (DNA hybridization).

^eEC₅₀ <0.32 µM in VCA ELISA.