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. Author manuscript; available in PMC: 2009 Apr 15.
Published in final edited form as: Dev Biol. 2008 Feb 15;316(2):441–455. doi: 10.1016/j.ydbio.2008.02.003

Figure 5.

Figure 5

Mia1 is expressed in regions of aberrant morphogenesis. Mia1 expression is restricted to the proximal epithelium in wild type E18.5 mice (A,B). Inducible misexpression of FGF7 in the lung epithelium causes widespread epithelial cell hyperplasia in E18.5 lungs (C), which is accompanied by sustained expression of Mia1 in virtually all epithelial cells (D). Inducible misexpression of FGF10 also causes epithelial cell hyperplasia (E), but in some areas focal adenomatous lesions are surrounded by normal tissue (asterisk). Mia1 is present in the areas of abnormal growth (F), but is absent in normal tissue. All panels are at the same magnification. qRT-PCR shows that Mia1 expression is significantly (*, p < 0.01 vs control lung, #, p < 0.01 vs adjacent lung) higher in independent lung tumors induced by urethane injection compared to lung tissue from control animals injected with saline, and to uninvolved lung tissue adjacent to the tumors (G). Data are plotted as means ± SE (n = 5).