Table 2.
Genes Changed by Misexpression of MIA
| Genbank Accession #
|
Fold Change
|
Symbol
|
Gene
|
|---|---|---|---|
| Transcription Factors | |||
| NM_007678 Protein | −1.7 | Cebpa | CCAAT/enhancer Binding (C/EBP), alpha |
| NM_010234 Oncogene | −1.6 | Fos | FBJ osteosarcoma related |
| NM_009331 Specific | −1.6 | Tcf7 | Transcription factor 7, T-cell |
| NM_010703 factor 1 | −1.6 | Lef1 | Lymphoid enhancer binding |
| NM_008259 | 1.6 | Foxa1 | Forkhead box A1 |
| NM_016768 transcription | 1.7 | Pbx3 | Pre B-cell leukemia factor 3 |
| NM_207215 | 1.7 | Phr1 | Pam, highwire, rpm 1 |
| NM_010574 | 1.7 | Irx2 | Iroquois related homeobox 2 |
| NM_177338 | 2.8 | Hmbox1 | Homeobox containing 1 |
| Development | |||
| NM_177905 (Drosophila) | −3.5 | Piwil4 | Piwi-like homolog 4 |
| XM_897426 | −2.9 | Plekhk1 | Pleckstrin homology domain containing, family K member |
| 1 | |||
| NM_133245 | −1.9 | Eraf | Erythroid associated factor |
| NM_011313 | −1.8 | S100a6 | S100 calcium binding protein |
| A6 | |||
| NM_008970 peptide | −1.7 | Pthlh | Parathyroid hormone-like |
| NM_010103 discoidin I-like | −1.7 | Edil3 | EGF-like repeats and domains 3 |
| NM_007447 | −1.7 | Ang1 | Angiogenin 1 |
| NM_054077 leucine- | −1.6 | Prelp | Proline arginine-rich end rich repeat |
| NM_009114 | −1.6 | S100a9 | S100 calcium binding protein |
| A9 NM_009627 | −1.5 | Adm | Adrenomedullin |
| XM_134149 homolog | 1.5 | Fath | Fat tumor suppressor |
| NM_172537 | 1.5 | Sema6d | Semaphorin 6D |
| NM_011350 | 1.6 | Sema4f | Semaphorin 4f |
| NM_010164 | 1.7 | Eya1 | Eyes absent 1 homolog |
| NM_031166 | 1.9 | Idb4 | Inhibitor of DNA binding 4 |
| NM_008520 factor | 1.9 | Ltbp3 | Latent transforming growth beta binding protein 3 |
| NM_007963 | 1.9 | Evi1 | Ecotropic viral integration |
| site 1 | |||
| NM_010181 | 2.4 | Fbn2 | Fibrillin 2 |
| NM_011674 | 2.5 | Ugt8 | UDP-glucuronosyltransferase |
| 8 | |||
| Signal Transduction | |||
| NM_008731 | −4.20 | Npy2r | Neuropeptide Y receptor Y2 |
| NM_007413 | −2.9 | Adora2b | Adenosine A2b receptor |
| NM_023635 | −2.6 | Rab27a | RAB27A |
| NM_013875 | −2.2 | Pde7b | Phosphodiesterase 7B |
| NM_144547 | −2.0 | Amhr2 | Anti-Mullerian hormone type receptor |
| 2 | |||
| NM_007592 | −2.0 | Car8 | Carbonic anhydrase 8 |
| NM_010407 | −1.8 | Hck | Hemopoietic cell kinase |
| NM_009217 | −1.7 | Sstr2 | Somatostatin receptor 2 |
| NM_021409 homolog | −1.6 | Pard6b | Partitioning defective 6 beta |
| NM_009062 signaling 4 | −1.6 | Rgs4 | Regulator of G-protein |
| NM_021099 | −1.6 | Kit | Kit oncogene |
| NM_025730 | −1.5 | Lrrk2 | Leucine-rich repeat kinase 2 |
| NM_138650 gamma | −1.5 | Dgkg | Diacylglycerol kinase, |
| NM_019725 split 2 | −1.5 | Tle2 | Transducin-like enhancer of homolog |
| NM_020505 | −1.5 | Vav3 | Vav 3 oncogene |
| NM_145566 like | 1.5 | Hrbl | HIV-1 Rev binding protein- |
| NM_013846 orphan | 1.6 | Ror2 | Receptor tyrosine kinase-like receptor 2 |
| XM_130346 155 | 1.7 | Gpr155 | G protein-coupled receptor |
| NM_019688 exchange | 1.7 | Rapgef4 | Rap guanine nucleotide factor 4 |
| NM_022721 | 1.7 | Fzd5 | Frizzled homolog 5 |
| NM_008965 | 1.7 | Ptger4 | Prostaglandin E receptor 4 |
| NM_009827 | 1.9 | Cckar | Cholecystokinin A receptor |
| NM_172815 | 2.9 | Rspo2 | R-spondin 2 homolog |
| Cell Adhesion | |||
| NM_001010937 channel | −4.4 | Gjb6 | Gap junction membrane protein beta 6 |
| NM_018857 | −2.3 | Msln | Mesothelin |
| XM_356226 homolog 3 | −1.9 | Fat3 | Fat tumor suppressor |
| NM_133721 | −1.7 | Itga9 | Integrin alpha 9 |
| NM_007734 | −1.6 | Col4a3 | Procollagen, type IV, alpha 3 |
| NM_009868 | −1.5 | Cdh5 | Cadherin 5 |
| NM_009903 | 1.7 | Cldn4 | Claudin 4 |
| NM_028078 | 1.7 | Jam4 | Junction adhesion molecule 4 |
| NM_007667 | 1.7 | Cdh8 | Cadherin 8 |
| NM_178382 | 1.8 | Flrt3 | Fibronectin leucine rich transmembrane protein 3 |
| NM_172862 matrix | 1.8 | Frem2 | Fras1 related extracellular protein 2 |
| NM_009864 | 1.9 | Cdh1 | Cadherin 1 |
| NM_007883 | 2.3 | Dsg2 | Desmoglein 2 |
| NM_028523 domain | 2.3 | Dcbld2 | Discoidin, CUB and LCCL containing 2 |
| NM_007663 | 2.9 | Cdh16 | Cadherin 16 |
| NM_019394 | 30.3 | Mia1 | Melanoma inhibitory activity |
| 1 | |||
| Transport | |||
| NM_009701 | −10.8 | Aqp5 | Aquaporin 5 |
| XM_130308 receptor- | −2.9 | Lrp2 | Low density lipoprotein related protein 2 |
| NM_133969 | −2.7 | Cyp4v3 | Cytochrome P450, family 4, subfamily v, polypeptide 3 |
| NM_013855 family A | −2.5 | Abca3 | ATP-binding cassette, sub-member 3 |
| NM_172621 | −2.0 | Clic5 | Chloride intracellular channel |
| 5 | |||
| NM_027491 | −1.9 | Rragd | Ras-related GTP binding D |
| NM_029310 gene | −1.8 | RIKEN cDNA 1700008G05 | |
| NM_011403 member 1 | −1.8 | Slc4a1 | Solute carrier family 4 |
| XM_130038 | −1.6 | Cubn | Cubilin |
| NM_153522 gated, type | −1.6 | Scn3b | Sodium channel, voltage-III, beta |
| NM_009197 member 2 | 1.5 | Slc16a2 | Solute carrier family 16 |
| NM_027052 member 4 | 1.5 | Slc38a4 | Solute carrier family 38, |
| NM_025383 associated 2 | 1.6 | Necap2 | NECAP endocytosis |
| NM_013569 channel, | 1.6 | Kcnh2 | Potassium voltage-gated subfamily H |
| NM_011985 | 1.7 | Mmp23 | Matrix metalloproteinase 23 |
| NM_172778 | 1.9 | Maob | Monoamine oxidase B |
| NM_053079 member 1 | 1.9 | Slc15a1 | Solute carrier family 15, |
| NM_018732 gated, type | 2.1 | Scn3a | Sodium channel, voltage-III, alpha polypeptide |
| NM_172613 | 2.4 | Atp13a4 | ATPase type 13A4 |
| NM_008557 ion | 2.4 | Fxyd3 | FXYD domain-containing transport regulator 3 |
| Lipid Metabolism | |||
| NM_009127 desaturase 1 | −30.3 | Scd1 | Stearoyl-Coenzyme A |
| NM_028765 like | −10.8 | Acoxl | Acyl-Coenzyme A oxidase- |
| NM_011134 | −8.8 | Pon1 | Paraoxonase 1 |
| NM_010052 | −4.1 | Dlk1 | Delta-like 1 homolog |
| NM_145376 | −4.1 | Aytl2 | Acyltransferase like 2 |
| NM_147779 | −2.7 | Sftpb | Surfactant associated protein |
| B | |||
| NM_023608 | −2.7 | Gdpd2 | Glycerophosphodiester phosphodiesterase domain containing 2 |
| NM_009128 desaturase 2 | −1.9 | Scd2 | Stearoyl-Coenzyme A |
| NM_008149 mitochondrial | −1.5 | Gpam | Glycerol-3-phosphate acyltransferase, |
| NM_175556 | 1.5 | Plch2 | Phospholipase C, eta 2 |
| NM_011921 family 1, | 1.6 | Aldh1a7 | Aldehyde dehydrogenase subfamily A7 |
| NM_146106 | 1.6 | Lyplal1 | Lysophospholipase-like 1 |
| NM_001004762 | 2.1 | Pla2g4c | Phospholipase A2, group (cytosolic, calcium-independent) |
| IVC | |||