Figure 3.

Schematic representation of the polypeptide chain arrangement of triabin. Acidic, basic, and cysteine residues are emphasized with red, blue, and yellow circles, respectively. Disulfide bridges are shown explicitly, and inter-main chain hydrogen bonds are represented as dotted lines. Residues involved in interactions with thrombin are shadowed in dark gray if in contact with Tyr-76 and/or Arg-77A, and in light gray otherwise. The shear number S equals the residue offset upon surrounding the barrel.